African American Artist outline Essay Example | Topics and Well Written Essays - 500 words

African American Artist outline - Essay Example Her mother did embroidery. Her father, a repair person and steelworker, jumped at the chance to tinker. An uncle was an artistic work painter. According to her authority site, Renee Stout experienced childhood in Pittsburgh, Pennsylvania and gained her BFA from Carnegie Mellon University in 1980. She started to investigate her African American legacy in 1985, when she moved to Washington, D.C. all around the African Diaspora, and in addition the world and her natures domain. Stout finds the motivation to make works that energize examination toward oneself, reinforcing toward herself and recovering toward oneself, bridling the conviction frameworks of African people groups and their descendants. Additionally, Stout utilization nonexistent characters to make a mixture of work of art, some of which incorporate: painting, blended media model, photography and establishment. Stout’s works portray some African influences. For instance, her artistic impacts incorporate Yoruba figure, and the nkisi consecrated items of the Central African Congo Basin. Other significant subjects in her work frequently incorporate Haitian Vodou, the space and society of New Orleans and the creole Voodoo specialist Marie Laveau. In a meeting led by Dr.o in her book Tales of the Conjure Woman, she affirms that keeping in mind the end goal to open the discussions, in regards to the set of relatives of African American society, she will keep rousing her takes a shot at topics, for example, African-determined profound conviction frameworks and Hodoo. She additionally concedes to needing to "possess a peculiar space inside the workmanship world- -a place that has more potential outcomes, both in vitality and spirit. She has taken part in various presentations including a few displays at the Smithsonian Institution in Washington, D.C. what is more at the De Beyerd Museum in the Netherlands. Her work is in various accumulations such as National Gallery of Art. In 2012 she

Operations management Essay Example | Topics and Well Written Essays - 500 words - 4

Operations management - Essay Example distribution to clients or customers along with purchasing activities with other vendors (Chidambaram, Whitman, & Cheraghi, â€Å"A Supply Chain Transformation Methodology†). With this concern it can be said that Ben and Jerry’s is playing a significant role by rendering its customers quality service through providing right product at the right time (Ben & Jerry’s, â€Å"Company†). The paper will be focused on providing a brief discussion about supply chain management of Ben & Jerry’s, an American ice-cream manufacturing enterprise along with its transformation methodology of providing their products in the global context. The various scopes of supply chain management of Ben & Jerry’s in the global operations has also been highlighted within the discussion (Chidambaram, Whitman & Cheraghi, â€Å"A Supply Chain Transformation Methodology†). The organizations in the present day context are highly focused to deliver their offerings according to the desires of the customers due to the immense growth in the communication networks along with changing face of globalization. Therefore, the competition within the enterprises can be considered to be extended globally in the modern business environment (Chidambaram, Whitman, & Cheraghi, â€Å"A Supply Chain Transformation Methodology†). The supply chain management system of Ben & Jerry is one of the effective tools for the organization in its endeavor to expand to more than 30 countries of the world. With the concept of effective global supply chain management system, the strategy of Ben & Jerry’s consigns transformation methodology along with making use of appropriate management techniques that help the enterprise to lead among the various competitors around the globe (Ben & Jerry’s, â€Å"Company†). In order to address the transformation related challenges on a global basis, Ben & Jerry’s focuses on various transformation steps for efficient supply chain management around its different units of enterprise.

Controlling Freedom Essay Example | Topics and Well Written Essays - 750 words

Controlling Freedom - Essay Example The propaganda model propsed by Chomsky argues that the maintenance of control over the media is a result of free market forces operating on a daily basis and does not necessarily require conscious planning. The framing of conditions and accidental necessity needed to do this can be compared to a that of a crystalline structure. By pouring a stream of balls over a flat box like frame we inevitably end up with a perfect pyramid structure. In the same way by pouring news, information and ideas into the basic framework of free market goals we end up with a self building pyramid where by supportive elements within the pyramid find themselves in stable positions and those unsupportive elements of the pyramid are simply forced out. The framing of these conditions which facilitate the building of these near perfect crystalline structures are called the five reality filters. The first filter is related to the size, ownership and expense of producing media. The second argues that the media ar e heavily dependent on advertising and sponsorship, thus content has to follow 'advertiser friendly lines' or risk loosing vital funding. Thirdly, resources are concentrated where significant news is likely to occur, while non routine sources of news often struggle to find access to the media. The fourth filter, called Flak, refers to the negative responses that are received by media due to a program or article. Just as supportive media is naturally assisted, unsupportive media is attacked and vilified. The last filter is called 'anti-communism' and refers to the need for a common enemy. Throughout history we see examples of the creation of new 'evil empires' ( communists , Islamic terrorists etc) which threaten the status quo, requiring the production of more arms and therefore increasing economic activity and generating important revenue. In testing the hypothesis there are numerous examples of media attention being directed to serve corporate interests and government agendas. Truth filtration also extends to media black holes, where unsuitable truths are simply not reported. A horrific example of this is East Timor, where Indonesian brutalities administered from weapons traded in multi million pound deals with the British, huge oil reserves and an amiable dictatorship ensured the smooth functioning of the filter system. The vast majority of the general public were unaware of the massive human rights abuses and atrocities taking place. Ignoring, silencing and not giving voices to those that contradict the 'line' is another filtration system which ensures the ongoing passivity of the general public. The Iraq war in 1993 saw the whipping up of an effective media campaign against Iraq and its evil dictator that had invaded Kuwait. The just and noble forces of freedom went into action backed by the media. Clark in his book The Fire This Time, US War Crimes in the Gulf demonstrates how the western version of media events was untrue and that the war was in fact set up, manipulated and brought about to remove obstructions to western economic interests. Other examples of the propaganda model in action can be seen with examples such as global warming. In 1990, despite government unanimity on its existence and the potentially

The courts decisions over the last thwenty five years or so reveal a Essay

The courts decisions over the last thwenty five years or so reveal a remarkably confusing approach to the purpose of cross-examination under s1(f)(ii)Criminal E - Essay Example gainst the national interest are easy to fathom and understand but lately, especially the last two decades, court decisions that require adjudication of cases in which the good or the bad moral character of the defendant is relevant to the resolution of the facts in issue, had been murky and muddled that students of law are often left befuddled. This is to be expected as the allowance of evidence of the bad or good moral character of the accused is fully in the discretion of the judges.3 Some jurors disallow hearing of evidence of the character of the accused on the pretext that it is irrelevant to the case. According to Elliott, â€Å"evidence is relevant when it has a tendency in reason to establish the probability or improbability of a fact in issue†4 Relevancy or the materiality to the issue of fact raised in the pleadings is extremely important because if evidence is relevant as well as competent, then that evidence is admissible. What is then relevant and thus admissible is therefore, dependent on the juror’s discretion. All that the court has to say after it refuses admittance of evidence is that it does so â€Å"in the interest of justice by virtue of Criminal Justice Act 1988 section 25(1).5 Wigmore’s Axiom of Admissibility which is supposed to facilitate the judges’ exercise of their discretion to allow or disallow admission of evidence as to the good or bad character of the accused merely confuse the judges and everybody else. According to Wigmore, what can be admitted are only facts with rational probative value unless some specific rule clearly forbids its admission. Again the term ‘rational probative value’ is dependent on the interpretation of each judge. The Alfred Altmore Pope Foundation case tersely expresses this dilemma: No precise and universal test of relevancy is furnished by the law but the determination of whether particular evidence is relevant rests largely on the discretion of the court, which must be exercised

Book Critique Family to Family Essay Example for Free

Book Critique Family to Family Essay Author Information The authors of the book are Jerry Pipes and Victor Lee. Content Summary In the book, Family to Family, Families Making a Difference, the writers detail the major premise of the work within its first few pages: â€Å"Family to Family will help you discover God’s purpose for your family, develop a family mission statement, establish core values, make time for quality and quantity family time centered around God’s purposes, and equip you to lead your children to Christ and mentor them spiritually† (3). The book’s purpose is to maximize family time in the Lord, bringing family members closer together by helping them actualize their standing first in Christ, and then as they relate and interact with each other. The book promotes the idea of discovering â€Å"the critical link between being on mission as a family and passing the baton of your faith on to your children† (3). This line of thought is prevalent in the book and it seems to summarize the mission of the writers. The book views itself as being based and rooted in the solid foundation of the scriptures, and the authors express as much: â€Å"The bottom lineGod’s plan for the family has been revealed in His Word†¦ The success of our families will be determined by our commitment to know and live the principles of God’s Word† (3). In the first chapter of the book, the writers make the contention that many families are not healthy and are not spending quality time with one another. The writers reference research gathered from The American Family Association and George Barna. Through the accumulated research, the writers state that, â€Å"only 34 percent of America’s families eat one meal together each day. (In addition) the average father spends only eight to 10 minutes a day with his children. This includes meal times.† (6) Another alarming statistic that they present to their audience is that â€Å"only 12 percent of America’s families pray together, (and) the average couple spends only four minutes of uninterrupted time together a day† (6). After the writers finish sharing some alarming statistics, they proceed to identify what a healthy Christian family should look like. They call for persons to examine their own families and to ask the following questions: Is it a cohesive unit or a disjointed collection of individuals? Is it on mission for God or unsure of its mission? Is it flowing or fumbling? Disciplined or destructive? Purposeful or pointless (7)? From the second chapter onward, the writers seek to allow the book to serve as a guide to nurture an unhealthy family as they move towards an improved level of spiritual health. The writers begin by proposing a family mission statement, stating that, â€Å"A family mission statement will serve as a centerline and guardrails for your family on the road through life† (25). The writers lead us on an extensive exposition on the importance of a familial mission statement and how to initiate one and incorporate one into our families. In chapter two, they present seven realities, which are geared towards accepting and incorporating the fact that God is and can be an ever-present reality within your family. The writers then discuss the importance of teaching and sharing the Gospel with children. They present the fact that 90 percent of all Christians have accepted Jesus before the age of 25, and therefore, place a premium on passing the baton onto the next generation as early as we can (51). The remainder of the book becomes a summary of other evangelical programs and ideas, shared in an effort to encourage the entire family to become an evangelizing force together. They include the models of concentric circles (75) and other familial evangelistic ideas, which are geared towards the family being unified and presenting that unification before others as a witness to their unity in Christ. In the final chapter of the book, the writers detail the importance of Biblical based evangelism for all of those persons involved in the family unit. The writers advocate what they call the FIRM approach to evangelism, which involves: F ask about family, I ask about their interests-listen, R ask about religion-listen, and M share the message (114-115). Lastly, the writers provide some practical methods for sharing the Gospel, which include some scripture memorization and tips on a salvation-testimony presentation. Evaluation The book seeks to establish a rationale for the disunity of the modern family and then to provide mechanisms to promote unity within the family through the Word, then to evangelize through the family as a united front in Christ. The book is short, efficient and to the point. It allows for easy reading and presents an effective rationale for families being unified first in Christ (with each other), and then presenting that unification as an active, vibrant testimony to others. The writers identify early on that this is a book for families in crisis, and the greatest contributing factor to that difficulty involves time and busyness within the members of the family itself. Due to the simplistic presentation of the material, the writers allow for a potential impact for a wide variety of persons and family units (beyond the traditional ones). The writer’s presentation of unhealthy families and the facts provided which detail children who have fallen away from the church cannot be understated in its level of importance, and serves to provide the reader with a foundation for the rest of the work. The flow of the work involves a clever method employed by the writers that mixes conversational and anecdotal stories with necessary information, which is important to hold the interest of the target audiences. The writers may have perhaps offered a more compelling argument, had they given their target audience a little more background information concerning the statistics they compiled, rather than just highlighting that information in endnotes. The chapter on mission statements feels rushed, and gives the impression that research for the work appears to be somewhat lacking. Case in point: there is no citation offered concerning the comparison of Jonathan Edwards and the Jukes families. This cannot help but offer the audience the false notion that the writers composed the necessary research to develop the notion they are putting forth (24-25). The writers provide another example without properly citing and giving credit to the source on page 26, in the example of the bucket of sand and the big rock and the little rock. This is an illustration which has been used by many in the past, and the writers are not the original source of it. They state, â€Å"Perhaps you have seen the illustration of the big rocks and little rocks† (26). Again, this may be nitpicking; however, I believe that they need to demonstrate responsibility, since the book is a Christian work. The book contains relevant study questions and provides a plethora of workbook-like material. That being said, the work is ideal for small group studies in the church and provides a foundational approach for working with families. Beyond being simple enough for the new convert to understand, the book is filled with practical and insightful applications for all believers to use in their endeavors to spread the Word within their families and to others. The writers have fulfilled their purpose in the book. It is obvious to see, with the statistics presented and the commentary offered, that families are in trouble and the church needs to respond to their needs. The church is comprised (mostly) of families. The enemy is aware that if he destroys the family unit (as presented in scripture), then he goes a long way to placing a major injury on the church. Pipes and Lee are to be commended for their efforts. They wrote Family to Family: Leaving a Lasting Legacy, as a reply to the susceptibility of even supposedly Christian families to the status quo. This status quo, as presented by the writers, involves an adherence to one of the varying levels of dysfunction that many families experience. The outline for families in the scriptures is one man, one woman, and if they are blessed, then children. This work provides an excellent evangelistic modality within which to engage all types of families (single parent, no children, etc). This is due to the fact that, regardless of the construction of the particular family, salvation is needed within and should be displayed cohesively to the world. That being said, one can see that, once a family mission statement is adopted, the potential for manipulation within a family is obvious. Potential problems could arise should one of the parents attempt to use the mission statement to manipulate their children to act and perform in the manner that they desire. Should conflict and divorce arise in the family (which is a startling reality for the church as well as the world), then these paradigms constructed originally to help could instead be used to further divide the entire family. With any risk of developing methodology and then instructing others to incorporate this methodology into their lives, without being able to control all extraneous variables (which only God can), there is the potential danger for some using the writer’s material for abusive purposes. Yet in taking this risk, the writers succeed. This is largely due to the fact that they speak the truth of the scriptures in love, and are to be applauded for developing and exhorting others to incorporate these methods into their lives to improve their families and evangelize the lost. There is something pure and right about someone trying to assist others whom are in desperate struggles in this life. The writers have presented a unique and challenging way for the church to implement and instruct families which are in desperate need of such tutoring. A most wonderful encapsulating quote is found on page 114, which states, â€Å"The bottom line is sharing the way of salvation through Jesus Christ. This is what this book is all about: raising your family to follow Christ. Following Christ means sharing the gospel with those who do not know Him. Jesus said, ‘Follow me, and I will make you fishers of men’ (Matt.4:19). If you are not fishing, you are not following. You and your family are on mission to be fishers of men† (114). This is a rousing call to families and the Body of believers. Those who endeavor to heed the call must realize the writer’s purposes in desiring to show them a way to raise their families to serve and follow Jesus. BIBLIOGRAPHY Pipes, Jerry and Victor Lee. Family to Family, Families Making a Difference. Lawrenceville, GA: Jerry Pipes Productions, 1999.

Psychology Vocab Essay Example for Free

Psychology Vocab Essay Anal stage: the stage at which children advocate erotic pleasure with the elimination process Archetype: an inherited idea, based on the experiences of one’s ancestors, which shapes one’s perception of the world Altered states of consciousness: conscious level, preconscious level, and unconscious level Amnesia: a loss of memory that may occur after a blow to the head or as a result of brain damage Biofeedback: the process of learning to control bodily states with the help of machines monitoring the states to be controlled Bipolar: a disorder in which a person’s mood inappropriately alternates between feelings of mania and depression Client centered therapy: an approach developed by Carl Rogers that reflects the belief that the client and therapist are partners in therapy Conditioning: a type of learning that involves stimulus response connections in which the response is conditional to the stimulus Central nervous system: Spinal cord and the brain Classical conditioning: a learning procedure in which associations are made between a natural stimulus and a neutral stimulus Collective unconscious: the part of the mind that inherited instincts, urges, and memories common to all people Consciousness: an individual’s state of awareness, including a person’s feelings, sensations, ideas, and perceptions Compulsion: an apparently irresistible urge to repeat an act or engage in ritualistic behavior such as hand washing Cross- sectional study: research method in which data is collected from groups of participants of different ages and compares so that conclusions can be drawn about differences due to age CS (Conditioned stimulus): a once neutral event that elicits a given response after a period of training in which it has been paired with an unconditioned stimulus CR (conditioned response): a response by the conditioned stimulus; it is similar to the unconditioned response, but not identical in magnitude or amount Defense mechanism: Certain specific means by which the ego unconsciously protects itself against unpleasant impulses or circumstances Dissociative identity disorder (multiple personality): a person exhibits two or more personality states, each with its own patterns of thinking and behaving Dependent variable: changes in relation to the independent variable Discrimination: the ability to respond differently to similar but distinct stimuli. 2. The unequal treatment of individuals on the basis of their race, ethnic group, age, gender, or membership in another category rather than on the basis of individual characteristics Depression: a psychological disorder characterized by extreme sadness, an inability to concentrate, and feelings of helplessness and dejection Superego: the part of the personality that is the source of conscience and contracts the socially undesirable impulses of the id Dopamine: Involved in learning, emotional, arousal, and movement Eidetic memory: the ability to remember with great accuracy visual information on the basis of short term exposure Extinction: in classical conditioning, the gradual disappearance of a conditional response because the reinforcement is withheld or because the conditioned stimulus is repeatedly presented without the unconditioned stimulus Endocrine system: a chemical communication system using hormones, by which messages are sent through the blood stream, EEG (electroencephalograph): a machine used to record the electoral activity of large portions of the brain Extravert: an outgoing, active person who directs his or her energies and interests toward other people and things Electroshock therapy: also called (ECT), an electrical shock is sent through the brain to try to reduce symptoms of mental disturbance Ego: the part of the personality that is in touch with reality and strives to meet the demands of the id and the superego in socially acceptable ways Free association: a Freudian technique used to examine the unconscious; the patients instructed to say whatever comes into his or her mind Formal operations: the person is able to solve abstract problems Fixed ratio schedule: a pattern of reinforcement in which a specific number of correct responses is required before reinforcement can be obtained Fixed interval schedule: a pattern of reinforcement in which a specific amount of time must elapse before a response will elicit reinforcement Functional fixedness: a mental set characterized by the inability to imagine new functions for familiar objects Genital Stage: Freud’s fifth and final psychosexual stage during which an individual’s sexual satisfaction depends as much on giving pleasure as on receiving it Hypothalamus: regulates the autonomic nervous system Hallucinations: perceptions that have no direct external cause Hypothesis: an assumption or prediction about behavior that is tested through scientific research Identity crisis: A period of inner conflict during which adolescents worry intensely about who they are Id: in psychoanalytic theory, that part of the unconscious personality that contains our needs, drives, and instincts, as well as repressed material Independent variable: experimenters change or alter so they can observe its effects Imprinting: inherited tendencies or responses that are displayed by newborn animals when they encounter new stimuli in their environment Introvert: a reserved, withdrawn person who is more preoccupied with his or her inner thoughts and feelings than in what is going on around him or her Imitation: The third way of learning Latency Stage: the fourth stage of Freud’s psychosexual development at which sexual desires are pushed into the background and the child becomes involved in exploring the world and learning new skills Long term memory: the storage of information over extended periods of time Longitudinal study: research method in which data is collected about a group of participants over a number of years to assess how certain characteristics change or remain the same during development Lithium carbonate: a chemical used to counteract mood swings of bipolar disorder Maturation: the internally programmed growth of a child Meditation: the focusing of attention to clear one’s mind and produce relaxation Modeling: the process of learning behavior through observation and imitation of others Mnemonic devices: techniques of memorizing information by forming vivid associations or images, which facilitate recall and decrease forgetting Negative reinforcement: increasing the strength of a given response by removing or preventing a painful stimulus when the response occurs Neurosis: One of the most commonly used diagnostic distinctions Oral Stage: Freud’s first stage of psychosexual development, in which infant’s associate erotic pleasure with the mouth Object permanence: Child’s realization that an object exists even when he or she cannot see or touch it Operant conditioning: a form of learning in which a certain action is reinforced or punished, resulting in corresponding increases or decreases in the likelihood that similar actions will occur again Obsession: a recurring thought or image that seems to be beyond control OCD (obsessive compulsive disorder): an anxiety disorder consisting of obsessions and compulsions Oedipus complex: seems more like a literary conceit that a thesis worthy of a scientifically minded psychologist Psychosexual stages: 1. Oral stage, 2.anal stage, 3.phallic stage, 4.latancy stage, 5.ganital stage Psychosocial stages: 1. Trust vs. mistrust, 2. Autonomy vs. Shame and doubt, 3.initiative vs. guilt, 4. Industry vs. inferiority, 5. Identity vs. role confusion, 6. Intimacy vs. isolation, 7. Generativity vs. stagnation, 8. Ego integrity vs. Despair Pre-operational stage: emerges when the child begins to use mental images symbols to understand things Pituitary gland: â€Å"master gland† Psychosis: One of the most commonly used diagnostic distinctions Projective test: an unstructured test of personality in which a person is asked to respond freely, giving his or her own interpretation of various ambiguous stimuli Phallic stage: Freud’s third psychosexual stage, children associate sexual pleasure with their genitals Psychology: the scientific, systematic study of behaviors and mental processes Psychiatry: a branch of medicine that deals with mental, emotional, or behavioral disorders Psychotherapy: a general term for the application of psychological principles and techniques for any treatment used by therapists to help troubled individuals overcome their problems and disorders Positive reinforce: a stimulus that increases the likelihood that a response will occur again Psychoanalysis: a form of therapy aimed at making patients aware of their unconscious motives so that they can gain control over their behavior and free themselves of self-defeating patterns Reli ability: the ability of a test to give the same results under similar conditions REM sleep: a stage of sleep characterized by rapid eye movements, a high level of brain activity, a deep relaxation of the muscles, and dreaming Reinforcement schedule: an important factor in operant conditioning Random sample: One way to avoid a nonrepresentative sample Rorschach inkblot cards: 10 cards with inkblot designs and a system for interpreting responses Self –actualization: the humanist term for realizing one’s unique potential Shaping: technique of operant conditioning in which the desired behavior is â€Å"molded† by first rewarding any act similar to that behavior and then requiring ever-closer approximations to the desired behavior before giving the reward Short term memory: memory that is limited in capacity to about seven items and in duration by the subject active rehearsal Spontaneous recovery: the reappearance of an extinguished conditioned response after some time has passed Selective attention: Focusing\ on only one detail of many Schizophrenia: a group of severe psychotic disorders characterized by confused and disconnected thoughts, emotions, behavior, and perceptions Separation anxiety: whenever the child is suddenly separated from the mother Superego: the part of the personality that is the source of conscience and contracts the socially undesirable impulses of the id Sensorimotor: the infant uses schemas that primarily involve his body and sensations Surrogate mothers: substitute mothers TAT (Thematic Apperception Test): This test consists of a series of pictures Thalamus: major relay station of the brain Unconscious: the part of the mind that holds mostly unacceptable thoughts, wishes, feelings, and memories of which we are unaware but that strongly influences conscious behaviors UCR (Unconditioned response): an organism, automatic or natural reaction to a stimulus UCS (unconditioned stimulus): an event that elicits a certain predictable response without previous training Variable- ratio schedule: a pattern of reinforcement in which a specific amount of time must elapse before a response will elicit reinforcement Variable- interval schedule: a pattern of reinforcement in which changing amounts of time must elapse before a response will obtain reinforcement Validity: the ability of a test to measure what it is intended to measure Theorists Carl Jung: (1875-1961) believed that people try to develop their potential as well as handle their instinctual urges. He distinguished between personal unconscious and the collective unconscious Alfred Adler: (1870-1937) believed that the driving force in people’s lives is a desire to overcome their feelings of inferiority Sigmund Freud: (1856-1939) believed that our conscious experiences are only the tip of the iceberg, that beneath the surface are primitive biological urges that are in conflict with the requirements of society and morality Erick Erickson: (1902-1994) believed that the need for social approval is just as important as a child’s sexual and aggressive urges Abraham Maslow: (1908-1970) tried to base his theory of personality on studies of healthy, creative, self actualizing people who fully utilize their talents and potential rather than on studies of disturbed individuals Carl Rogers: (1902-1987) believed that many people suffer from a conflict between wh at they value in themselves and what they believe that other people value in them John B. Watson 🙠 1878-1958) psychology should concern itself only with the observable facts of behavior. Said that all behavior is the result of conditioning and occurs because the appropriate stimulus is present in the environment Ivan Pavlov: (1849 -1936) charted another new course for psychological investigation. Demonstrated that a neutral stimulus can cause a formerly unrelated response B.F. Skinner 🙠 1904-1990) introduced the concept of reinforcement. Attempted to show how his laboratory techniques might be applied to society as a whole Albert Bandura: people direct their own behavior by their choice of models. Harry Harlow: (1905- 1981) studied the relationship between mother and child in a species closer to humans, the rhesus monkeys Galen: Identified four personality characteristics called melancholic, sanguine, choleric, and phlegmatic Alfred Binet: Karen Horney: (1885-1952) stressed the importance of basic anxiety. She believes that if a child is raised in an atmosphere of love and security, that child could avoid Freud’s psychosexual parent child conflict b Lawrence Kohlberg: His studies show how important being able to see other people’s points of view is to social development in general and to moral development of moral reasoning Jean Piaget: Discovered that knowledge builds as children grow. Children develop logic and think differently at different ages Lorenz Konrad: (1903- 1989) became a pioneer in the field of animal learning. He discovered that baby geese become attached to their mothers in a sudden, virtually permanent learning process called imprinting Stanley Milgram: conducted the most famous investigation of obedience in 1963. Wanted to determine whether participants would administer painful shocks to others merely because an authority figure had instructed them to do so James Marcia: main contribution is in clarifying the sources and nature of the adolescent identity crisis Philip Zimbardo: made the Zimbardo experiment Solomon Asch: designed what has become a classic experiment to test conformity to pressure from one’s peers Hermann Rorschach: made the inkblot test   Wilhelm Wundt: he proposed that psychological experience is composed of compounds, much like the ones found in chemistry Phillipe Pinel: Father of scientific psychiatry   Dorothea Dix: Chief spokesperson for reform

Advantages Of Semisynthetic Penicillins Biology Essay

Advantages Of Semisynthetic Penicillins Biology Essay Introduction Amoxycillin is a semisynthetic ÃŽ ²-lactam antibiotic derived from a common chemical nucleus of naturally occurring Penicillin G, 6-aminopenicillanic acid. Vital to Amoxycillins biological effects is the ÃŽ ²-lactam ring contained within this nucleus. Amoxicillin is bacteriolytic and bacteriocidal to susceptible gram positive and gram negative microbacteria. Today, amoxicillin is the 9th most prescribed drug in the world. Penicillin discovery Up until the early 1900s, the only treatment for bacterial infection was antiseptic which was only useful for surface wounds. In 1928, Alexander Fleming made a momentous albeit accidental discovery in St Marys Hospital in London. He noticed that a Staphylococci plate being grown in culture had been contaminated with mould of the species Penicillium notatum and that this had resulted in the inhibition of bacterial growth in the vicinity of the mould. Fleming subsequently isolated the mould and formulated an antibacterial mould broth. In 1938 at Oxford, Howard Florey and his biochemist Ernst Chain extracted penicillin from the mould and established that it was nontoxic and had chemotherapeutic effects. In 1941 an injectable form of penicillin became available for therapeutic use Advantageous of Semisynthetic Penicillins Penicillin G (naturally occurring) is poorly stable in gastric acid and broken down rapidly as it passes through the stomach. Therefore, Penicillin G must be given intramuscularly which limits its usefulness. Semisynthetic penicillins such as Amoxycillin with increased oral bioavailability were a major advancement in therapeutic antibiotics. Furthermore, while aminopenicillins and natural penicillins have similar efficacy against gram positive bacteria, semisynthetic aminopenicillins (such as Amoxycillin) are more active against certain strains of gram negative rods. Amoxycillin Discovery In Beecham Laboratories in 1957, 6-aminopenicillanic acid (6-APA) was isolate from penicillin. Through chemical modification of the ÃŽ ²-lactam thiazolidine ring side chains semisynthetic penicillins were developed. In 1961, Ampicillin was created which was quickly followed in 1964 by the introduction of a Ï -hydroxyl group in Ampicillins side chain creating amoxycillin. Amoxycillin was found to have improved absorption following oral administration and 2-2.5 times greater plasma concentrations compared to an equivalent dose of Ampicillin. In 1967 Beecham laboratories discovered that the susceptibility of Amoxycillin to ÃŽ ²-lactamase could be overcome with co-administration of clavulanic acid (a ÃŽ ²-lactamase inhibitor isolated from Streptomyces olivaceus). Chemistry Amoxycillin is a white crystalline powder that is somewhat soluble in alcohol and water. Amoxycillins chemical name is (2S,5R,6R)-6-[(R)-2amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethy;-7-oxo-4-thia-1-azabicyclo[3.2.0]heptanes-2-carboxylic acid. It has a molecular weight of 419.4. Figure 1: Chemical Structure of Amoxycillin Pharmacodynamics Amoxycillin functions by inhibiting the biosynthesis of cell wall mucopeptides of susceptible gram positive and negative microorganisms actively synthesizing peptidoglycan and undergoing multiplication. The molecular target of Amoxycillin and other ÃŽ ²-lactam antibiotics are the Penicillin Binding Proteins. Upon drug-target interaction transpeptidation is blocked and thus inhibiting the synthesis of peptidoglycan, a vital cell wall component. Subsequently, the inhibitor of autolytic enzymes in the cell wall, is removed resulting in active autolytic enzymes and bacteriolysis. Pharmacokinetics Amoxycillin complies with the two compartment model with elimination occurring from the central compartment. Figure 2 demonstrates Amoxycillins biexponential decline of serum concentration with time. Table 1 and 2 document the pharmacokinetic parameters of Amoxycillin. Figure 2: Average serum concentration versus time after 500mg IV dose of Amoxycillin. Table 1: Pharmacokinetic parameter and absolute bioavailability of a 500mg oral dose of Amoxycillin. Table 2: Pharmacokinetic parameter of a 500mg IV dose of Amoxycillin. Administration Amoxycillin is usually administered orally. The relationship between dose and extent of absorption is not linear with a plateau at higher oral concentrations. Dose adjustments need to be made in patients with renal dysfunction. Bioavailability Drug bioavailability is the proportion of drug that passes into systemic circulation after oral administration. It is dependent upon absorption across the gastrointestinal tract and first pass clearance by the liver. After oral administration of a dose of 250mg and 500mg of Amoxycillin the average peak serum concentrations (observed between 1-2 hours after administration) were 5.0mg/mL and 6.0 10.8 mg/mL respectively. The variation of plasma concentration with time is demonstrated in Figure 3. The oral bioavailability of Amoxycillin is 77.4% Amoxycillin is stable in gastric acid and is rapidly absorbed after oral administration regardless of absence or presence of food products and thus a high proportion of administered dose reaches the systemic circulation.. Figure 3: Mean serum levels following oral administration of 125mg and 250mg of Amoxycillin to 11 normal volunteers. (95% confidence). Volume of Distribution Volume of distribution is defined as the volume of fluid in which the amount of drug in the body would need to be uniformly distributed to produce observed plasma concentrations. Amoxycillin distributes widely and rapidly into most body tissues and fluid. Despite this, Amoxycillin remains extracellular due to lipid insolubility and thus does not cross the blood brain barrier unless the meninges are inflamed. Volume of distribution of Amoxycillin is 20.2L (0.3 L/kg). Clearance Clearance is defined as the volume of blood cleared of drug per unit time. It is dependent on renal excretion hepatic elimination. The clearance of Amoxycillin is 221mL/min. Renal Excretion Amoxycillin is excreted predominantly via the urine in biologically active form or as penicilloic acid. 75% of a 1 gram dose is excreted in the urine within 6 hrs (60% biologically active form, 15% is in the form of penicilloic acid). Biological Half life Elimination half life is defined by the time taken for the plasma concentration of drug to reach half the steady state concentration. The biological half life is 61.3 minutes with normal renal function. Half life increases with renal dysfunction. Clinical Uses Amoxycillin is a broad spectrum ÃŽ ²-lactam antibiotic with effectiveness against many pathogenic microorganisms. It is commonly used to treat bacterial infections such as otitis media, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, urinary tract infections, gonorrhoea and skin infections. Indications for use Location of infection Microorganism Skin and skin structure E coli, Staphylococcus, nonpenicillinase producing streptococcis Respiratory (Acute and chronic) nonpenicillinase producing E coli, Streptococcus, Strep. Pneumonia, H.influenzae, staphylococcus Genitourinary tract (Complicate and uncomplicated, acute and chronic) E.Coli, P.mirabilis and Strep. Faecalis Gonorrhoea N. Gonorrhoea (nonpenicillinase producing) Prophylaxis of endocarditis Used in people at particular risk (e.g. individuals who have previously had endocarditis or with a prosthetic heart valve) Table 3: Indications for use of Amoxycillin Precautions Drug interactions Amoxycillin is rarely associated with adverse drug interactions however the following reactions have been demonstrated in some cases. Drug Interaction Oral anticoagulants (e.g. Warfarin and Acenocoumarol) Results in abnormal prolongation of prothrombin time (or international normalised ratio.) Allopurinol Results in increased rate of rash reactions. It is unknown whether this is due to Amoxycillin reacting with the allopurinol itself or the hyperuricaemia that it is treating. Combined Oral Contraceptives Like all penicillin, Amoxycillin can affect the commensal gut flora which results in decreased oestrogen absorption. This has been associated with decreased efficacy of combined oral contraceptives. Tetracyclines or other bacteriostatic drugs Bacteriostatic drugs have been known to interference with the bactericidal effects of Amoxycillin Clavulanic acid Amoxycillin therapeutic effects are inactivated by penicillinase (ÃŽ ²-lactam) producing organisms. It is possible to co-administer Amoxycillin with clavulanic acid (ÃŽ ²-lactamase inhibitor) to broaden the spectrum of susceptible bacteria (e.g.. co-amoxiclav). Probenecid Renal excretion can be delayed by administration of Probenecid as demonstrated by Figure 4. When used in conjunction there is an increased plasma concentration of Amoxycillin reached and longer duration of effect. This is a beneficial interaction. Table 4: Some common drug interactions when co-administered with Amoxycillin Figure 4: Mean serum levels following oral administration of 1 gram of Amoxycillin with and without probenicid. Pregnancy and Lactation While penicillin can cross the placenta, no teratogenic effects have been uncovered through animal studies. Similarly, Amoxycillin can be excreted in breast milk resulting in potential side effects for the nursing infant including diarrhoea or allergic response. However, Amoxycillin is generally considered safe for use in pregnant women and nursing mothers. Adverse reactions Side effects are uncommon however potentially include insomnia, diarrhoea, dizziness, confusion, heartburn, easy bruising, itching, nausea, vomiting, abdominal pain, bleeding, rash and allergic reactions. The most common adverse reaction is hypersensitivity reactions in patients with allergies to ÃŽ ² lactam antibiotics, penicillin or cephalosporins. Anaphylaxis can be fatal and occurs more frequently following parenteral administration. All penicillins have been associated with seizures when administered in excessive doses or administered intrathecally. Conclusion The discovery of penicillin by Alexander Flemming lead to the subsequent generation of the semisynthetic aminopenicillin, Amoxycillin. This ÃŽ ²-lactam antibiotic has a broad spectrum of therapeutic use, high oral bioavailability and lack of toxic effects.